The potential role of long non-coding RNA Dnm3os in the activation of cardiac fibroblasts

• Published in: Sheng wu yi xue gong cheng xue za zhi Vol. 38; no. 3; p. 574
• Main Authors: Kong, Qihang, Zhou, Junteng, Tian, Geer, Quan, Yue, Wu, Wenchao, Liu, Xiaojing
• Format: Journal Article
• Language: Chinese
• Published: China Sichuan Society for Biomedical Engineering 25.06.2021
• Subjects: Aorta; Collagen; Contraction; Fibroblasts; Fibrosis; Growth factors; Heart; Humans; Lung diseases; Myocardium - pathology; Non-coding RNA; Phenotypes; Polymerase chain reaction; RNA, Long Noncoding; Signal processing; Signal Transduction; siRNA; Smad2 protein; Thorax; Transforming Growth Factor beta1; Transforming growth factor-b1; transforming growth factor-β1/Smad2/3; cardiac fibrosis; long non-coding RNA Dnm3os; cardiac fibroblast activation

Long non-coding RNA (lncRNA) Dnm3os plays a critical role in peritendinous fibrosis and pulmonary fibrosis, but its role in the process of cardiac fibrosis is still unclear. Therefore, we carried out study by using the myocardial fibrotic tissues obtained by thoracic aortic constriction (TAC) in an...