An Fe complex for 19F magnetic resonance-based reversible redox sensing and multicolor imaging

We report a first-in-class responsive, pentafluorosulfanyl (–SF5)-tagged 19F MRI agent capable of reversibly detecting reducing environments via an FeII/III redox couple. In the FeIII form, the agent displays no 19F MR signal due to paramagnetic relaxation enhancement-induced signal broadening; howe...

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Published inChemical science (Cambridge) Vol. 14; no. 19; pp. 5099 - 5105
Main Authors Kadakia, Rahul T, Ryan, Raphael T, Cooke, Daniel J, Que, Emily L
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 17.05.2023
The Royal Society of Chemistry
Subjects
Chemistry
Displays
Hypoxia
Magnetic resonance
Oxidation
Reduction
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Summary:We report a first-in-class responsive, pentafluorosulfanyl (–SF5)-tagged 19F MRI agent capable of reversibly detecting reducing environments via an FeII/III redox couple. In the FeIII form, the agent displays no 19F MR signal due to paramagnetic relaxation enhancement-induced signal broadening; however, upon rapid reduction to FeII with one equivalent of cysteine, the agent displays a robust 19F signal. Successive oxidation and reduction studies validate the reversibility of the agent. The –SF5 tag in this agent enables ‘multicolor imaging’ in conjunction with sensors containing alternative fluorinated tags and this was demonstrated via simultaneous monitoring of the 19F MR signal of this –SF5 agent and a hypoxia-responsive agent containing a –CF3 group.
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These authors contributed equally to this work.
ISSN:2041-6520
2041-6539
DOI:10.1039/d2sc05222a