Effect of verapamil on chemiluminescence of peripheral blood neutrophils during hemodialysis in chronic uremic patients

Luminol-dependent chemiluminescence of resting and opsonized zymosan-activated neutrophils isolated from the peripheral blood was determined in 10 chronic uremic patients during early period of hemodialysis without verapamil or preceded by verapamil injection. Verapamil was found to diminish depress...

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Published inArchivum Immunologiae et Therapiae Experimentalis Vol. 37; no. 1-2; p. 149
Main Authors Pawlicki, L, Tchórzewski, H, Trznadel, K, Luciak, M, Kantorski, J, Pokoca, L
Format Journal Article
LanguageEnglish
Published Switzerland 1989
Subjects
Adult
Cell Count
Cell Division - drug effects
Chronic Disease
Female
Free Radicals
Humans
Kidney Failure, Chronic - metabolism
Male
Neutrophils - drug effects
Neutrophils - metabolism
Oxygen - metabolism
Renal Dialysis
Verapamil - pharmacology
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Summary:Luminol-dependent chemiluminescence of resting and opsonized zymosan-activated neutrophils isolated from the peripheral blood was determined in 10 chronic uremic patients during early period of hemodialysis without verapamil or preceded by verapamil injection. Verapamil was found to diminish depression of neutrophil chemiluminescence both at rest and following activation with opsonized zymosan. The drug also diminished transient hemodialysis neutropenia. The results seem to indicate that verapamil may exert beneficial effects on inflammatory reactions induced by hemodialysis in chronic uremics.
ISSN:0004-069X