Derivatives of benzo(c)fluorene. X. Inhibitory effect of Benfluron on cellular immunity

The effect of a cytostatic drug Benfluron-- 5(2-N,N-dimethyl-amino-ethoxy)-7-oxo-7H-benzo(c)fluorene hydrochloride was tested in mice on skin graft survival, graft-versus-host reaction (GVHR) and for mitogenic stimulation of human lymphocytes. Application of Benfluron resulted in a prolonged skin gr...

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Published inNeoplasma Vol. 31; no. 4; pp. 399 - 406
Main Authors Paluska, E, Hrubá, A, Soucek, J, Danĕk, P F, Chudomel, V, Pujman, V, Krepelka, J
Format Journal Article
LanguageEnglish
Published Slovakia 1984
Subjects
Animals
Antineoplastic Agents - pharmacology
Cell Survival - drug effects
Female
Fluorenes - pharmacology
Graft vs Host Reaction - drug effects
Graft vs Host Reaction - radiation effects
Humans
Immunity, Cellular - drug effects
Lymphocyte Activation - drug effects
Male
Mice
Mice, Inbred Strains
Skin - cytology
Skin - drug effects
Skin Transplantation
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Summary:The effect of a cytostatic drug Benfluron-- 5(2-N,N-dimethyl-amino-ethoxy)-7-oxo-7H-benzo(c)fluorene hydrochloride was tested in mice on skin graft survival, graft-versus-host reaction (GVHR) and for mitogenic stimulation of human lymphocytes. Application of Benfluron resulted in a prolonged skin graft survival. The regional and systemic GVHR was potentially inhibited by p. o. administration of Benfluron at a dose of 100 mg/kg of body weight. Allogeneic spleen cells incubated with Benfluron at concentration of 5-20 micrograms/ml showed reduced capability to induce GVHR. PHA or PWM stimulation of lymphocytes was completely inhibited in the presence of 2 micrograms/ml Benfluron. Benfluron as a potent immunosuppressive agent can be considered useful for the prevention of GVHR.
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ISSN:0028-2685