Chromosome alterations in cancer development and apoptosis

Normal somatic cells are programmed to die (or undergo apoptosis) whereas cancer cells program themselves to survive. Some of the cytogenetic alterations that might be involved in apoptosis and continuous cell proliferation of normal and cancer cells such as shortening of telomeres, formation of dic...

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Bibliographic Details
Published inIn vivo (Athens) Vol. 8; no. 5; p. 843
Main Authors Pathak, S, Dave, B J, Gagos, S
Format Journal Article
LanguageEnglish
Published Greece 01.11.1994
Subjects
Aneuploidy
Animals
Apoptosis - genetics
Caenorhabditis - genetics
Cellular Senescence
Chromosome Aberrations
Chromosome Banding
Chromosome Deletion
Drosophila - genetics
Humans
Karyotyping
Mammals
Neoplasms - genetics
Neoplasms - pathology
Neoplasms - physiopathology
Polyploidy
Telomere - ultrastructure
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Summary:Normal somatic cells are programmed to die (or undergo apoptosis) whereas cancer cells program themselves to survive. Some of the cytogenetic alterations that might be involved in apoptosis and continuous cell proliferation of normal and cancer cells such as shortening of telomeres, formation of dicentric chromosomes, transfer of telomeric DNA to the homologous chromosomes, malfunction (inactivation) of the centromeres, endoreduplication of chromosomes and other structural and numerical chromosome abnormalities are discussed here.
ISSN:0258-851X