Urologic chronic pelvic pain syndrome--looking back and looking forward

Urologic chronic pelvic pain syndrome (UCPPS) is a symptom-based umbrella term for interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men. Unfortunately, no gold standard for diagnosis or treatment of UCPPS exists. We review seve...

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Bibliographic Details
Published inFolia medica (Plovdiv) Vol. 51; no. 3; pp. 42 - 44
Main Authors Dimitrakov, Jordan, Dimitrakova, Elena
Format Journal Article
LanguageEnglish
Published Bulgaria MEDICAL UNIVERSITY- PLOVDIV 01.07.2009
Subjects
Chronic Disease
Cystitis, Interstitial - etiology
Genomics
Humans
Male
Pelvic Pain - etiology
Prostatitis - etiology
Proteomics
Syndrome
Systems Biology
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Summary:Urologic chronic pelvic pain syndrome (UCPPS) is a symptom-based umbrella term for interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men. Unfortunately, no gold standard for diagnosis or treatment of UCPPS exists. We review several emerging theories on the etiology and pathogenesis of UCPPS with a special emphasis on genomic and proteomic technologies. We also propose a systems-biology approach to elucidating the pathogenetic mechanisms implicated in UCPPS and the discovery and validation of new biomarkers for UCPPS. Using data gleaned from high-throughput genomic and proteomic screens can help develop effective treatments for this enigmatic chronic pelvic pain syndrome.
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ISSN:0204-8043
1314-2143