Immunogenicity and reactogenicity of two regimens of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio and Haemophilus influenzae type B vaccines administered to infants primed at birth with hepatitis B vaccine

• Published in: Southeast Asian journal of tropical medicine and public health Vol. 35; no. 3; pp. 685 - 692
• Main Authors: HENG KOCK CHENG, RAJADURAI, V. S, AMIN, Z, SRIRAM, B, YEE, M. F, HAN, H. H, BOCK, H. L, SAFARY, A
• Format: Journal Article
• Language: English
• Published: Bangkok Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network 01.09.2004
• Subjects: Antibodies, Bacterial - biosynthesis; Antibodies, Bacterial - blood; Antibodies, Viral - biosynthesis; Antibodies, Viral - blood; Bacterial diseases; Biological and medical sciences; Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage; Diphtheria-Tetanus-Pertussis Vaccine - adverse effects; Diphtheria-Tetanus-Pertussis Vaccine - immunology; Drug Interactions; Ent and stomatologic bacterial diseases; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Haemophilus Vaccines - administration & dosage; Haemophilus Vaccines - adverse effects; Haemophilus Vaccines - immunology; Hepatitis B Vaccines - administration & dosage; Hepatitis B Vaccines - adverse effects; Hepatitis B Vaccines - immunology; Human bacterial diseases; Humans; Immunization Schedule; Infant; Infant, Newborn; Infectious diseases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Other diseases. Semiology; Poliovirus Vaccine, Inactivated - administration & dosage; Poliovirus Vaccine, Inactivated - adverse effects; Poliovirus Vaccine, Inactivated - immunology; Safety; Vaccines, Combined - adverse effects; Vaccines, Combined - immunology; Vaccines, Conjugate - adverse effects; Vaccines, Conjugate - immunology; Human; Nervous system diseases; Respiratory disease; Hepatic disease; Infant; Acute anterior poliomyelitis; Vaccine; Diphtheria; Birth; Haemophilus influenzae; Whooping cough; Infection; Pasteurellaceae; Prevention; Hepatitis; Immunogenicity; Viral disease; Central nervous system disease; Bacteriosis; Digestive diseases; Bacteria; Tropical medicine; Tetanus; Spinal cord disease
• ISSN: 0125-1562

An open, randomized study evaluated the immune response and safety of two different regimens of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b (DTPa-HBV-IPV-Hib) immunization in infants primed at birth with hepatitis B vaccine. One-half of the 150 healthy, full-term infants received a DTPa HBV-IPV-Hib vaccine at 1 1/2, 3 and 5 months of age; the other received a DTPa-IPV-Hib vaccine at 1 1/2, 3 and 5 months of age with separate HBV vaccine at 1 and 5 months of age. Immune response was similar following the two regimens with 100% of the vaccinees seroprotected for HBV, diphtheria, tetanus, Hib and poliovirus types 2 and 3 diseases after the full vaccination course. One vaccinee in the DTPa HBV-HPV- Hib group failed to respond to the poliovirus type 1 antigen. Response to the three pertussis antigens ranged from 92-97% in the DTPa-IPV-Hib plus separate HBV group and 100% in the DTPa HBV-IPV-Hib group. The most frequently reported post-vaccination symptoms were irritability in the DTPa-IPV-Hib plus separate HBV group (49% of vaccinees) and fever, defined as axillary temperature > or =37.5 degrees C, in the DTPa HBV- IPV-Hib group (50% of vaccinees).