Expression of hydra head activator in newt tissues and effects on limb regeneration

In this study, the presence of the hydra head activator (HHA) neuropeptide and its influence on regenerating newt limbs (Notophthalmus viridescens) was investigated. Immunohistological analysis has localized the HHA neuropeptide in the adult newt brain, eye, intestine, and regenerating blastema. Exp...

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Bibliographic Details
Published inIn vivo (Athens) Vol. 7; no. 1; p. 59
Main Authors Fuentes, E J, Mescher, A L, Ekman, R, Tsonis, P A
Format Journal Article
LanguageEnglish
Published Greece 01.01.1993
Subjects
Amino Acid Sequence
Animals
Brain Chemistry - physiology
Cell Division - physiology
Cyclic AMP - metabolism
Cyclic GMP - metabolism
Extremities - physiology
Eye - chemistry
Immunohistochemistry
Intestines - chemistry
Molecular Sequence Data
Neuropeptides - analysis
Pyrrolidonecarboxylic Acid - analogs & derivatives
Regeneration - physiology
Salamandridae - metabolism
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Summary:In this study, the presence of the hydra head activator (HHA) neuropeptide and its influence on regenerating newt limbs (Notophthalmus viridescens) was investigated. Immunohistological analysis has localized the HHA neuropeptide in the adult newt brain, eye, intestine, and regenerating blastema. Experiments in which 9 day limb regenerates were denervated and subsequently implanted with HHA-soaked beads suggest a slight progression of blastema growth compared to denervated controls.
ISSN:0258-851X
1791-7549