Sirolimus: mammalian target of rapamycin inhibitor to prevent kidney rejection

Current immunosuppressive therapies are effective but can be associated with significant adverse reactions. Sirolimus works differently from the immunosuppressants currently available, and except for increased lipid levels, the adverse reaction profile of sirolimus does not appear to overlap to any...

Full description

Saved in:
Bibliographic Details
Published inNephrology nursing journal : journal of the American Nephrology Nurses' Association Vol. 27; no. 6; p. 623
Main Authors Cowan, P A, Heizer, K E
Format Journal Article
LanguageEnglish
Published United States Anthony J. Jannetti, Inc 01.12.2000
Subjects
Blood & organ donations
Clinical Trials as Topic
Drug Costs
Drug Interactions
Drug therapy
Graft Rejection - etiology
Graft Rejection - prevention & control
Humans
Immunosuppression - adverse effects
Immunosuppression - methods
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - immunology
Immunosuppressive Agents - therapeutic use
Intestinal Absorption
Kidney Transplantation - immunology
Kidneys
Nurse's Role
Patient Selection
Renal Dialysis
Safety
Sirolimus - adverse effects
Sirolimus - immunology
Sirolimus - therapeutic use
Transplantation Immunology - immunology
Transplants & implants
Treatment Outcome
Online AccessGet full text

Cover

More Information
Summary:Current immunosuppressive therapies are effective but can be associated with significant adverse reactions. Sirolimus works differently from the immunosuppressants currently available, and except for increased lipid levels, the adverse reaction profile of sirolimus does not appear to overlap to any great extent with that associated with cyclosporine or tacrolimus. While additional research is needed, the initial clinical data in kidney recipients suggest that sirolimus, in combination with cyclosporine or tacrolimus, might have the potential to reduce the frequency of rejection episodes, permit reductions in cyclosporine or tacrolimus dosage, and permit steroid withdrawal (Kelly, 1999).
ISSN:1526-744X
2163-5390