Unveiling the Therapeutic Potential of Systemic Ozone on Skin Wound Repair: Clinical, Histological, and Immunohistochemical Study in Rats

According to a systematic review [34], wounds treated with topical ozone had a greater reduction in wound size. [...]this study is aimed at assessing the impacts of systemic ozone (O3) therapy and the influence of various dosages of the O3/O2 mixture on the healing of open wounds induced on the dors...

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Bibliographic Details
Published inBioMed research international Vol. 2024
Main Authors Jânderson de Medeiros Cardoso, Ervolino, Edilson, Miyasawa, Erton Massamitsu, Theodoro, Leticia Helena, Marques Padovan, Luis Eduardo, Estevão Lopes Pereira, Rafael Scaf de Molon, Valdir Gouveia Garcia
Format Journal Article
LanguageEnglish
Published New York Hindawi Limited 20.08.2024
Subjects
Dentistry
Growth factors
Hypotheses
Immunohistochemistry
Laboratory animals
Ozone
Skin
Wound healing
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Summary:According to a systematic review [34], wounds treated with topical ozone had a greater reduction in wound size. [...]this study is aimed at assessing the impacts of systemic ozone (O3) therapy and the influence of various dosages of the O3/O2 mixture on the healing of open wounds induced on the dorsum of rats. During the experimental period, the animals were provided with crushed solid food (Presence Feed, Primor S.A. Mill, São Paulo, SP) and had access to water “ad libitum.” Sample Calculation The sample size calculation was conducted using the GPower® program, considering an alpha (Type I) and beta (Type II) error of 5% and 80%, respectively, and a medium effect size of ES=0.25.
ISSN:2314-6133
2314-6141
DOI:10.1155/2024/6623114