Aetiology of diarrhoea in pre-term neonates at Kenyatta National Hospital nursery, Nairobi, Kenya

• Published in: East African medical journal Vol. 67; no. 4; p. 223
• Main Authors: Mutanda, L N, Patel, A, Masudi, A M, Maina, G
• Format: Journal Article
• Language: English
• Published: Kenya 01.04.1990
• Subjects: Cross Infection - epidemiology; Cross Infection - microbiology; Diarrhea, Infantile - epidemiology; Diarrhea, Infantile - microbiology; Disease Outbreaks; Escherichia coli Infections - epidemiology; Escherichia coli Infections - microbiology; Hospitals, Public; Humans; Infant, Newborn; Infant, Premature; Kenya; Nurseries, Hospital; Salmonella Infections - epidemiology; Salmonella Infections - microbiology; Serotyping; Kenya
• ISSN: 0012-835X

The aetiology of two outbreaks of diarrhoea in pre-term neonates (March-August; September, 1987), at Kenyatta National Hospital was studied. The first outbreak involved 98 neonates and enteropathogenic E. coli of different serotypes were the most commonly isolated agents (54%), with serotype 086a:K61 dominating. These were followed by Salmonella (16%) also of different groups, and then rotavirus (6%). Two campylobacter and two Shigella were isolated from four individual neonates. Mixed infections were mainly those of Salmonella and E. coli (5 cases). E. coli serotype 086 was found to be in circulation throughout the study period (March-August, 1987), whilst 044:0125 and 0128 circulated for a limited period. Salmonella and some strains of E. coli caused persistent diarrhoea despite antibiotic therapy. Nosocomial infections were found to play a role in subsequent diarrhoeas. In the second diarrhoea outbreak, again enteropathogenic E. coli and Salmonella were the most frequently isolated. However, in this outbreak, there was no single E. coli serotype revealed that some possessed plasmids of 120-160 megadalton. However, a search for human immunodeficiency viral antibodies in 120 stools produced negative results.