Genetic polymorphism of immunoglobulin G in the mink. VI. A regulatory gene controlling the expression of the gamma-chain constant region allotype of mink immunoglobulin
We describe here the inheritance of H6, one of the six known allotypes of the gamma-chain constant region of mink immunoglobulin (IgG). H6 is not present in minor concentrations in the serum, and its phenotypic expression is stable. However, in offspring of some of (H6-)X(H6-) crosses. H6 appeared u...
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| Published in | Experimental and clinical immunogenetics Vol. 7; no. 4; p. 213 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
1990
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| Abstract | We describe here the inheritance of H6, one of the six known allotypes of the gamma-chain constant region of mink immunoglobulin (IgG). H6 is not present in minor concentrations in the serum, and its phenotypic expression is stable. However, in offspring of some of (H6-)X(H6-) crosses. H6 appeared unexpectedly and, by contrast, it disappeared in some H6+/H6+ homozygote offspring. Based on pedigree analysis, a transregulation of H6 expression in the serum by an autosomal recessive gene not linked to the structural allotype gene is postulated. |
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| AbstractList | We describe here the inheritance of H6, one of the six known allotypes of the gamma-chain constant region of mink immunoglobulin (IgG). H6 is not present in minor concentrations in the serum, and its phenotypic expression is stable. However, in offspring of some of (H6-)X(H6-) crosses. H6 appeared unexpectedly and, by contrast, it disappeared in some H6+/H6+ homozygote offspring. Based on pedigree analysis, a transregulation of H6 expression in the serum by an autosomal recessive gene not linked to the structural allotype gene is postulated. |
| Author | Fomicheva, I I Volkova OYu |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/2128024$$D View this record in MEDLINE/PubMed |
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| Snippet | We describe here the inheritance of H6, one of the six known allotypes of the gamma-chain constant region of mink immunoglobulin (IgG). H6 is not present in... |
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| SubjectTerms | Animals Gene Expression Regulation Genes, Immunoglobulin Genes, Recessive Genes, Regulator Immunoglobulin Allotypes - biosynthesis Immunoglobulin Allotypes - genetics Immunoglobulin G - genetics Immunoglobulin gamma-Chains - genetics Mink - genetics Mink - immunology Pedigree Phenotype Polymorphism, Genetic |
| Title | Genetic polymorphism of immunoglobulin G in the mink. VI. A regulatory gene controlling the expression of the gamma-chain constant region allotype of mink immunoglobulin |
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