Genetic polymorphism of immunoglobulin G in the mink. VI. A regulatory gene controlling the expression of the gamma-chain constant region allotype of mink immunoglobulin

We describe here the inheritance of H6, one of the six known allotypes of the gamma-chain constant region of mink immunoglobulin (IgG). H6 is not present in minor concentrations in the serum, and its phenotypic expression is stable. However, in offspring of some of (H6-)X(H6-) crosses. H6 appeared u...

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Bibliographic Details
Published inExperimental and clinical immunogenetics Vol. 7; no. 4; p. 213
Main Authors Fomicheva, I I, Volkova OYu
Format Journal Article
LanguageEnglish
Published Switzerland 1990
Subjects
Animals
Gene Expression Regulation
Genes, Immunoglobulin
Genes, Recessive
Genes, Regulator
Immunoglobulin Allotypes - biosynthesis
Immunoglobulin Allotypes - genetics
Immunoglobulin G - genetics
Immunoglobulin gamma-Chains - genetics
Mink - genetics
Mink - immunology
Pedigree
Phenotype
Polymorphism, Genetic
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Summary:We describe here the inheritance of H6, one of the six known allotypes of the gamma-chain constant region of mink immunoglobulin (IgG). H6 is not present in minor concentrations in the serum, and its phenotypic expression is stable. However, in offspring of some of (H6-)X(H6-) crosses. H6 appeared unexpectedly and, by contrast, it disappeared in some H6+/H6+ homozygote offspring. Based on pedigree analysis, a transregulation of H6 expression in the serum by an autosomal recessive gene not linked to the structural allotype gene is postulated.
ISSN:0254-9670