Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11-16

Because the authors selected older patients (>60 years) for their study, we cannot exclude that the A-allele is enriched due to an associated protective survival effect. [...]even with the strong functional data of which we do not doubt the quality, the report of a functional relevant genetic THP...

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Published inNeuron (Cambridge, Mass.) Vol. 48; no. 5; p. 704
Main Authors Glatt, Charles E, Carlson, Elaine, Taylor, Travis R, Risch, Neil, Reus, Victor I, Schaefer, Catherine A
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 08.12.2005
Subjects
Age
Depressive Disorder, Major - genetics
Ethnicity
Humans
Mutation
Patients
Tryptophan Hydroxylase - genetics
Belgium
Sweden
Online AccessGet full text
ISSN0896-6273
1097-4199
1097-4199
DOI10.1016/j.neuron.2005.11.017

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Summary:Because the authors selected older patients (>60 years) for their study, we cannot exclude that the A-allele is enriched due to an associated protective survival effect. [...]even with the strong functional data of which we do not doubt the quality, the report of a functional relevant genetic THP2 polymorphism associated with affective disorders is at this stage uncertain and needs to be replicated independently.
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ISSN:0896-6273
1097-4199
1097-4199
DOI:10.1016/j.neuron.2005.11.017