Randomized comparative trials of single doses of the newer antischistosomal drugs at Mwanza, Tanzania. I. Praziquantel and oxamniquine for the treatment of schistosomiasis mansoni

Randomized single-blind comparative trials of the newer antischistosomal drugs praziquantel and oxamniquine were undertaken at Mwanza, Tanzania, an area coendemic for schistosomiasis mansoni and haematobium. The objective was to compare praziquantel, having broad-spectrum activity, with oxamniquine...

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Bibliographic Details
Published inJournal of tropical medicine and hygiene Vol. 87; no. 6; p. 231
Main Authors Rugemalila, J B, Asila, J, Chimbe, A
Format Journal Article
LanguageEnglish
Published England 01.12.1984
Subjects
Adolescent
Child
Clinical Trials as Topic
Feces - parasitology
Female
Humans
Isoquinolines - therapeutic use
Male
Nitroquinolines - therapeutic use
Oxamniquine - administration & dosage
Oxamniquine - therapeutic use
Parasite Egg Count
Praziquantel - administration & dosage
Praziquantel - therapeutic use
Random Allocation
Schistosoma mansoni
Schistosomiasis - drug therapy
Tanzania
Tanzania
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Summary:Randomized single-blind comparative trials of the newer antischistosomal drugs praziquantel and oxamniquine were undertaken at Mwanza, Tanzania, an area coendemic for schistosomiasis mansoni and haematobium. The objective was to compare praziquantel, having broad-spectrum activity, with oxamniquine when administered in single doses for levels of tolerance, symptomatic relief, and reduction in schistosome egg output in schistosomiasis mansoni. Whereas the single oral doses of 40 mg/kg and 15 mg/kg for praziquantel and oxamniquine respectively were nearly equally well tolerated, praziquantel showed significantly better efficiency to commend it as a drug of choice for chemotherapy for control programmes, besides its acknowledged place in the clinical management of individual patients.
ISSN:0022-5304