The various clinical patterns of xanthoma disseminatum. Considerations on seven cases and review of the literature

Xanthoma disseminatum (XD) is a rare mucocutaneous xanthoma nowadays classified as a benign non-Langerhans cell histiocytosis. We studied 7 cases of XD with a long follow-up and reviewed the literature in order to compare and discuss previous reports. We studied clinical manifestations, course, hist...

Full description

Saved in:
Bibliographic Details
Published inDermatology (Basel) Vol. 190; no. 1; p. 19
Main Authors Caputo, R, Veraldi, S, Grimalt, R, Gianotti, R, Tosti, A, Varotti, C, de Kaminsky, A R
Format Journal Article
LanguageEnglish
Published Switzerland 1995
Subjects
Adult
Age of Onset
Diabetes Insipidus - complications
Female
Histiocytosis, Non-Langerhans-Cell - diagnosis
Histiocytosis, Non-Langerhans-Cell - etiology
Histiocytosis, Non-Langerhans-Cell - physiopathology
Histiocytosis, Non-Langerhans-Cell - therapy
Humans
Immunohistochemistry
Infant
Male
Microscopy, Electron
Prognosis
Skin - pathology
Treatment Failure
Online AccessGet more information

Cover

More Information
Summary:Xanthoma disseminatum (XD) is a rare mucocutaneous xanthoma nowadays classified as a benign non-Langerhans cell histiocytosis. We studied 7 cases of XD with a long follow-up and reviewed the literature in order to compare and discuss previous reports. We studied clinical manifestations, course, histopathologic, ultrastructural and immunohistochemical findings of 7 cases of XD followed for 1-20 years. We report our findings and compare our cases with those described in the literature. XD and Langerhans cell histiocytosis were distinguished by clinical differences, as well as ultrastructural and immunohistochemical methods. Three clinical patterns of XD appeared to emerge in our group of patients and in the cases reviewed from the literature.
ISSN:1018-8665
DOI:10.1159/000246628