Structural genes of coagulation factors VII and X located on 13q34

From 7 cases of abnormalities involving chromosome 13, the structural gene(s) coding for coagulation factors VII and X were located in the region 13q34-13qter. Gene-dosage effects for these coagulation factors seem to act in both directions, causing a decrease when there is monosomy of segment 13q34...

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Bibliographic Details
Published inAnnales de génétique Vol. 29; no. 1; p. 32
Main Authors Gilgenkrantz, S, Briquel, M E, André, E, Alexandre, P, Jalbert, P, Le Marec, B, Pouzol, P, Pommereuil, M
Format Journal Article
LanguageEnglish
Published Netherlands 1986
Subjects
Adolescent
Child
Child, Preschool
Chromosome Aberrations - blood
Chromosome Aberrations - genetics
Chromosome Deletion
Chromosome Disorders
Chromosomes, Human, 13-15
Factor VII - genetics
Factor VII - metabolism
Factor X - genetics
Factor X - metabolism
Female
Genes
Humans
Infant
Male
Translocation, Genetic
Trisomy
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Summary:From 7 cases of abnormalities involving chromosome 13, the structural gene(s) coding for coagulation factors VII and X were located in the region 13q34-13qter. Gene-dosage effects for these coagulation factors seem to act in both directions, causing a decrease when there is monosomy of segment 13q34, but also, as has not been demonstrated before, an increase when there is trisomy of this same segment.
ISSN:0003-3995