Serological profiles for HBV, HDV, HIV-1 and HTLV-1 in Saudi patients with a malignancy

Serologic markers for HBV, HDV, HIV-1 and HTLV-1 were tested in 42 patients with a primary hepatocellular carcinoma (PHC); 19 with a malignancy of epithelial origin (EPM) and 16 with a non-epithelial malignancy (NEPM) in the Gizan Area of Saudi Arabia. HBV exposure in 77 PHC, EPM and NEPM patients w...

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Published inJournal of communicable diseases Vol. 23; no. 4; p. 270
Main Authors Arya, S C, Ashraf, S J, Pathak, V P, Nanda, V, Parande, C M, Tajuddin, S
Format Journal Article
LanguageEnglish
Published India 01.12.1991
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Carcinoma, Hepatocellular - complications
Female
Hepatitis B - blood
Hepatitis B - epidemiology
Hepatitis B - etiology
Hepatitis D - blood
Hepatitis D - epidemiology
Hepatitis D - etiology
HIV Infections - blood
HIV Infections - epidemiology
HIV Infections - etiology
HIV-1
HTLV-I Infections - blood
HTLV-I Infections - epidemiology
HTLV-I Infections - etiology
Humans
Liver Neoplasms - complications
Male
Middle Aged
Saudi Arabia - epidemiology
Seroepidemiologic Studies
Saudi Arabia
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Summary:Serologic markers for HBV, HDV, HIV-1 and HTLV-1 were tested in 42 patients with a primary hepatocellular carcinoma (PHC); 19 with a malignancy of epithelial origin (EPM) and 16 with a non-epithelial malignancy (NEPM) in the Gizan Area of Saudi Arabia. HBV exposure in 77 PHC, EPM and NEPM patients was 92.2 per cent for any marker (overall) while 75.3 per cent positive for HBsAg. 3.9 per cent positive for anti-HBc and 12.9 per cent positive for anti-HBs. There was no inter PHC, EPM, NEPM or intersex variation for an individual marker or total HBV exposure. Among HBsAg-positives, 9 of the 12 PHC tested, 7 of the 10 EPM, 1 of the 9 NEPM were anti-D IgG positive. The HDV prevalence was the lowest in NEPM (p < 0.01). In patients with a malignancy, all HBV and HDV markers were higher than those of control population, even though anti-HBs was lower (p < 0.001). The probable contribution through different viruses in pathogenesis of malignancies of different types should be ascertained through polymerase chain reaction for viral components, oncogenes, etc. on tumourous biopsy tissues. The aggravation in PHC morbidity in HBV hyperendemic foci through HIV infection should be monitored through tests for unintegrated and integrated viral DNA in tumorous and non-tumorous tissues.
ISSN:0019-5138