Glomerulopressin in end-stage renal disease. Effect of hemodialysis

Plasma and hemofiltrate activities and hemodialysis (HD) clearance of glomerulopressin (GP) were measured in eight end-stage renal disease (ESRD) patients. Four normal volunteers served as controls. Plasma GP was elevated significantly in the ESRD group and fell with HD. Significant amounts of GP we...

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Bibliographic Details
Published inASAIO transactions Vol. 37; no. 3; p. M235
Main Authors Zhou, X J, Vaziri, N D, Kaupke, C J
Format Journal Article
LanguageEnglish
Published United States 01.07.1991
Subjects
Adult
Female
Glomerular Filtration Rate - physiology
Glucuronates - blood
Humans
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - therapy
Kidney Glomerulus - physiopathology
Male
Metabolic Clearance Rate - physiology
Middle Aged
Renal Dialysis
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Summary:Plasma and hemofiltrate activities and hemodialysis (HD) clearance of glomerulopressin (GP) were measured in eight end-stage renal disease (ESRD) patients. Four normal volunteers served as controls. Plasma GP was elevated significantly in the ESRD group and fell with HD. Significant amounts of GP were found in the hemofiltrate. Single passage through the dialyzer resulted in a 24.7% fall in plasma GP activity. Dialyzer clearance of GP averaged 144 ml/min (75.4% of urea clearance). In conclusion, plasma GP was elevated in ESRD and readily removed by HD.
ISSN:0889-7190