Iron status of Filipino infants and preschoolers using plasma ferritin and transferrin receptor levels

• Published in: Southeast Asian journal of tropical medicine and public health Vol. 27; no. 2; pp. 343 - 349
• Main Authors: KUIZON, M. D, MADRIAGA, J. R, DESNACIDO, J. A, CHEONG, R. L, PERLAS, L. A
• Format: Journal Article
• Language: English
• Published: Bangkok Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network 01.06.1996
• Subjects: Anemia, Iron-Deficiency - blood; Anemia, Iron-Deficiency - epidemiology; Anemias. Hemoglobinopathies; Biological and medical sciences; Child; Child Nutrition Disorders - blood; Child Nutrition Disorders - epidemiology; Child, Preschool; Diseases of red blood cells; Ferritins - blood; Hematologic and hematopoietic diseases; Hemoglobins - analysis; Humans; Infant; Infection - complications; Medical sciences; Nutrition Surveys; Philippines - epidemiology; Receptors, Transferrin - blood; Reproducibility of Results; Sensitivity and Specificity; Tropical medicine; Asia; Philippine Islands; Philippines; Human; Measurement; Transferrin; Iron deficiency anemia; Nutrition disorder; Ferritin; Infant; Receiver; Hemopathy; Medical screening; Blood plasma; Association; Hemoglobin; Sideropenia; Malnutrition; Child
• ISSN: 0125-1562

Iron status of 1,861 Filipino infants and preschoolers was evaluated by measurements of plasma ferritin (PF), transferrin receptor (TR) and hemoglobin (Hb). One group of subjects (Group I) consisted of all anemic subjects together with a systematic subsample from the Fourth National Nutrition Survey-Biochemical Phase. Results showed that depleted iron stores based on PF (< 12.0 ng/ml) was present in 70.0% of infants and 60.5% of preschoolers. Tissue iron deficiency based on TR (> 8.5 mg/l) was present in higher proportion (80.0% and 73.7% for infants and preschoolers) which was comparable to the proportion of anemia (80.3%). In a subgroup of subjects from the Country Program for Children IV (Group 2) elevated TR was present in 61.4% of infants and 46.5% of preschoolers. A lower proportion of depleted iron stores of 22.7% in infants and 15.2% in preschoolers was observed. Correlation test showed that there was a closer relationship between Hb and TR (r = -0.42) than Hb and PF (r = 0.20) even if PF was expected to give a higher proportion of values below normal. The occurrence of anemia in the presence of elevated TR without any decrease in PF values suggest that the diagnostic ability of PF could be limited in the presence of infection. Therefore, future studies should include biochemical tests such as C-reactive proteins (CRP) to determine the extent of association between anemia and infection.