Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity

A case of reversible encephalopathy after one dose of ifosfamide/mesna in an epileptic 15-year-old girl is reported. No other pathology could be responsible for the symptoms. An epilepsy or a toxicity induced by vincristine were discussed. Nevertheless, the possible role of phenobarbital, known to i...

Full description

Saved in:
Bibliographic Details
Published inBulletin du cancer Vol. 75; no. 4; p. 391
Main Authors Ghosn, M, Carde, P, Leclerq, B, Flamant, F, Friedman, S, Droz, J P, Hayat, M
Format Journal Article
LanguageEnglish
Published France 1988
Subjects
Adolescent
Brain Diseases - chemically induced
Drug Interactions
Drug Therapy, Combination
Epilepsy - drug therapy
Female
Humans
Ifosfamide - adverse effects
Mercaptoethanol - analogs & derivatives
Mesna - adverse effects
Phenobarbital - metabolism
Phenobarbital - therapeutic use
Online AccessGet more information

Cover

More Information
Summary:A case of reversible encephalopathy after one dose of ifosfamide/mesna in an epileptic 15-year-old girl is reported. No other pathology could be responsible for the symptoms. An epilepsy or a toxicity induced by vincristine were discussed. Nevertheless, the possible role of phenobarbital, known to induce hepatic microsomal activity, seems the more probable mechanism.
ISSN:0007-4551