Marihuana attenuates the rise in plasma ethanol levels in human subjects

This study was conducted to determine if plasma ethanol levels are altered as a result of smoking marihuana. Fifteen healthy adult male volunteers who used ethanol and marihuana on a casual basis participated in this study. Subjects were randomly assigned to one of three groups: placebo, low-dose, o...

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Published inNeuropsychopharmacology (New York, N.Y.) Vol. 7; no. 1; pp. 77 - 81
Main Authors LUKAS, S. E, BENEDIKT, R, MENDELSON, J. H, KOURI, E, SHOLAR, M, AMASS, L
Format Journal Article
LanguageEnglish
Published New York, NY Nature Publishing 01.08.1992
Subjects
Adult
Alcohol Drinking
Alcoholism and acute alcohol poisoning
Analysis of Variance
Biological and medical sciences
Dose-Response Relationship, Drug
Dronabinol - pharmacology
Ethanol - blood
Humans
Male
Marijuana Smoking - blood
Medical sciences
Toxicology
Human
Poison interaction
Ethanol
Psychotropic
Marihuana
Oral administration
Drug of abuse
Normal
Pharmacokinetics
Inhalation
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Summary:This study was conducted to determine if plasma ethanol levels are altered as a result of smoking marihuana. Fifteen healthy adult male volunteers who used ethanol and marihuana on a casual basis participated in this study. Subjects were randomly assigned to one of three groups: placebo, low-dose, or high-dose marihuana. The marihuana dose was held constant and each subject drank three different doses of ethanol on 3 separate days spaced at least 1 week apart. Subjects drank either placebo or ethanol at doses of 0.35 g/kg (7.60 mmol/kg) or 0.70 g/kg (15.19 mmol/kg). Thirty minutes after drinking they smoked either a placebo marihuana cigarette, or one containing either 1.26% or 2.53% delta 9-tetrahydrocannabinol. Plasma ethanol levels rose sharply after the 0.7 g/kg dose and peaked at 50 minutes after drinking began (78.25 +/- 4.95 mg/dl). When subjects smoked the high-dose marihuana cigarettes after the 0.7 g/kg dose of ethanol, peak plasma ethanols levels were only 54.80 +/- 8.32 mg/dl at 105 minutes after drinking began. These alterations in plasma ethanol levels paralleled a reduction in the duration of ethanol- and marihuana-induced subjective effects after high doses of both drugs. These data suggest that marihuana may alter ethanol bioavailability.
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ISSN:0893-133X
1740-634X