Brainstem lesions in the course of chronic fetal asphyxia

We present a neuropathological study of brainstem involvement during the neonatal period, under the influence of prolonged fetal asphyxia. The investigation was performed on 20 brains of premature and mature newborns, who died in the course of chronic asphyxia. Ischemic cell change, neuronal loss an...

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Bibliographic Details
Published inClinical neuropathology Vol. 6; no. 3; p. 110
Main Authors Dambska, M, Laure-Kamionowska, M, Liebhart, M
Format Journal Article
LanguageEnglish
Published Germany 01.05.1987
Subjects
Brain Diseases - congenital
Brain Diseases - pathology
Brain Stem - pathology
Chronic Disease
Female
Fetal Hypoxia - complications
Fetal Hypoxia - pathology
Humans
Infant, Newborn
Infant, Newborn, Diseases - pathology
Infant, Premature
Pregnancy
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Summary:We present a neuropathological study of brainstem involvement during the neonatal period, under the influence of prolonged fetal asphyxia. The investigation was performed on 20 brains of premature and mature newborns, who died in the course of chronic asphyxia. Ischemic cell change, neuronal loss and gliosis were present in the brainstem of all infants. Two topographic patterns of brainstem lesions in chronic anoxic encephalopathy were distinguishable in the newborns. The neurons of the cranial nerve nuclei were more severely damaged in the group of premature newborns. More severe lesions of the reticular formation were found in the group of mature newborns. The topography of brainstem damage seems to be dependent on the maturity of CNS structures at the time of injury.
ISSN:0722-5091