Tumor necrosis factor alpha levels in serum and cerebrospinal fluid of patients with AIDS

We used a sensitive enzyme-linked immunosorbent assay technique to measure tumor necrosis factor alpha (TNF alpha) levels in serum and cerebrospinal fluid (CSF) samples from 30 patients infected with human immunodeficiency virus type 1 and from 10 normal controls. We found detectable levels of TNF a...

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Bibliographic Details
Published inFunctional neurology Vol. 7; no. 1; p. 35
Main Authors Franciotta, D M, Melzi d'Eril, G L, Bono, G, Brustia, R, Ruberto, G, Pagani, I
Format Journal Article
LanguageEnglish
Published Italy 01.01.1992
Subjects
Acquired Immunodeficiency Syndrome - diagnosis
Acquired Immunodeficiency Syndrome - immunology
Adult
AIDS Dementia Complex - diagnosis
AIDS Dementia Complex - immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Neurologic Examination
Opportunistic Infections - diagnosis
Opportunistic Infections - immunology
Tumor Necrosis Factor-alpha - cerebrospinal fluid
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Summary:We used a sensitive enzyme-linked immunosorbent assay technique to measure tumor necrosis factor alpha (TNF alpha) levels in serum and cerebrospinal fluid (CSF) samples from 30 patients infected with human immunodeficiency virus type 1 and from 10 normal controls. We found detectable levels of TNF alpha in 19 of 30 CSF and in 17 of 30 serum samples. The values of TNF alpha ranged between 20-90 pg/ml. All the patients had overt AIDS. More elevated TNF alpha levels in CSF correlate with focal damage within the central nervous system (p less than 0.01). Our results suggest that an intrathecal production of TNF alpha may occur during active inflammation in course of AIDS.
ISSN:0393-5264
1971-3274