JAK2, a third member of the JAK family of protein tyrosine kinases

We have isolated cDNA clones encoding a third, widely expressed, member of the JAK family of protein tyrosine kinases (PTKs). The anticipated amino acid sequence of JAK2 predicts the presence of two kinase-related domains, a feature characteristic of this family of PTKs. The structural similarity of...

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Bibliographic Details
Published inOncogene Vol. 7; no. 7; p. 1347
Main Authors Harpur, A G, Andres, A C, Ziemiecki, A, Aston, R R, Wilks, A F
Format Journal Article
LanguageEnglish
Published England 1992
Subjects
Amino Acid Sequence
Animals
Base Sequence
Janus Kinase 1
Janus Kinase 2
Mice
Molecular Sequence Data
Protein-Tyrosine Kinases - chemistry
Protein-Tyrosine Kinases - genetics
Proteins - chemistry
Proto-Oncogene Proteins
Sequence Homology, Nucleic Acid
TYK2 Kinase
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Summary:We have isolated cDNA clones encoding a third, widely expressed, member of the JAK family of protein tyrosine kinases (PTKs). The anticipated amino acid sequence of JAK2 predicts the presence of two kinase-related domains, a feature characteristic of this family of PTKs. The structural similarity of JAK2 to the other members of this family extends towards their N-termini, beyond the two kinase-related domains, and reveals five further domains of substantial amino acid similarity. The C-terminal portion of one of these domains, the JH4 domain, bears an intriguing, albeit tenuous, similarity to the core element of the SH2 domain, whereas the remaining JAK homology domains do not appear to be a feature of other known proteins.
ISSN:0950-9232