Amenorrhea-galactorrhea, hyperprolactinemia, and suprasellar pituitary enlargement as presenting features of primary hypothyroidism

Two women who presented with amenorrhea-galactorrhea and hyperprolactinemia associated with x-ray evidence of pituitary enlargement and suprasellar extension were found to have primary hypothyroidism. Resolution of the pituitary enlargement and galactorrhea occurred after thyroid hormone replacement...

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Bibliographic Details
Published inObstetrics and gynecology (New York. 1953) Vol. 63; no. 3 Suppl; p. 86S
Main Authors Groff, T R, Shulkin, B L, Utiger, R D, Talbert, L M
Format Journal Article
LanguageEnglish
Published United States 01.03.1984
Subjects
Adult
Amenorrhea - etiology
Female
Galactorrhea - etiology
Humans
Hypertrophy
Hypothyroidism - blood
Hypothyroidism - complications
Hypothyroidism - diagnosis
Hypothyroidism - diagnostic imaging
Lactation Disorders - etiology
Pituitary Gland - diagnostic imaging
Pituitary Gland - pathology
Pregnancy
Prolactin - blood
Radiography
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Summary:Two women who presented with amenorrhea-galactorrhea and hyperprolactinemia associated with x-ray evidence of pituitary enlargement and suprasellar extension were found to have primary hypothyroidism. Resolution of the pituitary enlargement and galactorrhea occurred after thyroid hormone replacement. Both women spontaneously ovulated and conceived, and normal pregnancies resulted. Amenorrhea, galactorrhea, and/or pituitary enlargement may be the principal manifestations of primary hypothyroidism. In such patients, it is imperative that primary hypothyroidism be excluded before drug or surgical therapy for presumed prolactinoma is undertaken. When these findings are due to primary hypothyroidism, thyroid hormone replacement alone is adequate therapy.
ISSN:0029-7844
1873-233X