Patterns of stromal elements in an implanted ureteric transitional cell carcinoma. An immunohistochemical and ultrastructural study

The results of the study of three implanted ureteric tumors from a primary transitional cell carcinoma of the renal pelvis are reported. Using both light microscopic immunohistochemistry and transmission electron microscopy, the stroma of the tumor showed consistent evidence for the production of at...

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Bibliographic Details
Published inEuropean urology Vol. 13; no. 1-2; p. 79
Main Authors Al-Zuhair, A G, Al-Adnani, M S, Al-Bader, A A, Ek, A G, Sabha, M
Format Journal Article
LanguageEnglish
Published Switzerland 1987
Subjects
Carcinoma, Transitional Cell - analysis
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - ultrastructure
Collagen - analysis
Histocytochemistry
Humans
Keratins - analysis
Kidney Neoplasms - pathology
Neoplasm Invasiveness
Ureteral Neoplasms - analysis
Ureteral Neoplasms - pathology
Ureteral Neoplasms - ultrastructure
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Summary:The results of the study of three implanted ureteric tumors from a primary transitional cell carcinoma of the renal pelvis are reported. Using both light microscopic immunohistochemistry and transmission electron microscopy, the stroma of the tumor showed consistent evidence for the production of at least its collagenous component by the neoplastic cells. Our findings argue with the notion that occasional fibroblasts and other cells of mesenchymal origin could play a major role in this phenomenon. Therefore, it seems plausible to suggest that what is happening in these tumors is similar to the behavior of malignant cells in scirrhous 'infiltrating' carcinoma of the breast and other sites.
ISSN:0302-2838
1873-7560
DOI:10.1159/000472741