Two cases of autoimmune progesterone dermatitis: immunohistochemical and serological studies

Two cases of autoimmune progesterone dermatitis are reported. The patients developed recurrent pruritic erythematous and edematous eruptions on the extremities, trunk or face, with occasional vesicles on the palms and soles. The eruptions appeared 7 to 10 days prior to their menstruation and persist...

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Bibliographic Details
Published inActa dermato-venereologica Vol. 69; no. 4; pp. 308 - 310
Main Authors MIURA, T, MATSUDA, M, YANBE, H, SUGIYAMA, S
Format Journal Article
LanguageEnglish
Published Uppsala Acta dermato-venereologica 1989
Subjects
Adult
Allergic diseases
Autoimmune Diseases - drug therapy
Autoimmune Diseases - immunology
Biological and medical sciences
Dermatitis - drug therapy
Dermatitis - immunology
Female
Histamine H1 Antagonists - therapeutic use
Humans
Immunoglobulin E - analysis
Immunopathology
Medical sciences
Menstruation
Progesterone - immunology
Skin allergic diseases. Stinging insect allergies
Skin Tests
Steroids - therapeutic use
Time Factors
Immunohistochemistry
Immunopathology
Autoimmune disease
Skin disease
Progesterone
Dermatitis
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Summary:Two cases of autoimmune progesterone dermatitis are reported. The patients developed recurrent pruritic erythematous and edematous eruptions on the extremities, trunk or face, with occasional vesicles on the palms and soles. The eruptions appeared 7 to 10 days prior to their menstruation and persisted for several days. They showed immediately positive skin tests with 0.1 mg/ml and 0.2 mg/ml of aqueous progesterone suspension, respectively. The patients had IgG serum factor which bound rat corpus luteum. Positive indirect basophil degranulation tests against progesterone were demonstrated in both patients. Circulating autoantibodies to patients' own progesterone may cause or modulate the intermittent eruptions of the disease.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ISSN:0001-5555
1651-2057