Clinicopathological study of the diffuse sclerosing variety of papillary cancer of the thyroid. Presentation of 4 new cases and review of the literature

A new variant of papillary carcinoma of the thyroid is analysed, known as 'diffuse sclerosing'. This lesion is characterized by a papillary cancer with a marked lymphocytic infiltration, intense fibrosis and a large number of psammoma bodies. Of a population of 158 differentiated thyroid c...

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Bibliographic Details
Published inEuropean journal of surgical oncology Vol. 20; no. 1; p. 7
Main Authors Moreno Egea, A, Rodriguez Gonzalez, J M, Sola Perez, J, Soria, T, Parrilla Paricio, P
Format Journal Article
LanguageEnglish
Published England 01.02.1994
Subjects
Adult
Carcinoma, Papillary - pathology
Female
Humans
Male
Middle Aged
Sclerosis
Thyroid Neoplasms - pathology
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Summary:A new variant of papillary carcinoma of the thyroid is analysed, known as 'diffuse sclerosing'. This lesion is characterized by a papillary cancer with a marked lymphocytic infiltration, intense fibrosis and a large number of psammoma bodies. Of a population of 158 differentiated thyroid carcinomas, we found four cases of this rare variant. The clinicopathological characteristics were studied together with the importance of an accurate diagnosis and prognosis, and the data obtained were compared with those of a 'well-differentiated or classical' papillary cancer, which yielded the following outstanding features: (a) younger age of presentation; (b) greater affinity for males; (c) greater frequency of extrathyroid extension; and (d) greater frequency of recurrences. The clinical importance of recognizing this variant is based on the need to apply a more aggressive treatment and a more exhaustive follow-up to such patients.
ISSN:0748-7983