Mycobacterial infection in HIV+ patients detected with a new immunological method (TB test)

• Published in: Allergie et immunologie Vol. 25; no. 1; p. 24
• Main Authors: Vanacore, R, Paladini, A, Ceretelli, S, Savalli, E, Sbrana, S, Falsini, R, Scasso, A, Ambrogi, F
• Format: Journal Article
• Language: English
• Published: France 01.01.1993
• Subjects: AIDS-Related Opportunistic Infections - complications; AIDS-Related Opportunistic Infections - diagnosis; AIDS-Related Opportunistic Infections - microbiology; Antibodies, Bacterial - blood; Antibodies, Bacterial - immunology; Antigens, Bacterial - immunology; Enzyme-Linked Immunosorbent Assay; HIV Seropositivity - complications; Humans; Immunoglobulin G - analysis; Membrane Glycoproteins - immunology; Mycobacterium Infections - complications; Mycobacterium Infections - diagnosis; Mycobacterium Infections - microbiology; Mycobacterium Infections, Nontuberculous - complications; Mycobacterium Infections, Nontuberculous - diagnosis; Mycobacterium Infections, Nontuberculous - microbiology; Mycobacterium tuberculosis - immunology; Mycobacterium tuberculosis - isolation & purification; Tuberculosis, Pulmonary - complications; Tuberculosis, Pulmonary - diagnosis; Tuberculosis, Pulmonary - microbiology
• ISSN: 0397-9148

Antibody response to antigen A60 (a mycobacterial antigen) was evaluated in ELISA in 18 HIV+ subjects with clinical and cultural evidences of mycobacterial infections, in 10 HIV+ subjects without Mycobacterial infections and in 22 healthy donors. We found higher levels of specific IgG in the HIV+ patients with Mycobacterial infections (mean 179.2 +/- 83 U) compared to the values of the donors (mean 92.5 +/- 35.5 U: p < 0.01). This test may be useful in the diagnosis of tuberculosis, but it needs clinical validation.