Hypogonadotrophic variant of Klinefelter's syndrome. A case report

A 16-year-old boy with 47,XXY chromosomal complement (Klinefelter's syndrome) presented with delayed puberty and apparent gonadotrophin deficiency. Despite an inadequate growth hormone response to insulin-induced hypoglycaemia and to L-dopa administration, his somatic growth was appropriate for...

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Bibliographic Details
Published inSouth African medical journal Vol. 74; no. 4; pp. 181 - 183
Main Authors WITTENBERG, D. F, PADAYACHI, T, NORMAN, R. J
Format Journal Article
LanguageEnglish
Published Pinelands Medical Association of South Africa 20.08.1988
Subjects
Adolescent
Gonadotropins, Pituitary - deficiency
Humans
Klinefelter Syndrome - physiopathology
Male
Pituitary Function Tests
Puberty, Delayed
Human
Klinefelter syndrome
Variant
Africa
Adolescent
Observation
South Africa
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Summary:A 16-year-old boy with 47,XXY chromosomal complement (Klinefelter's syndrome) presented with delayed puberty and apparent gonadotrophin deficiency. Despite an inadequate growth hormone response to insulin-induced hypoglycaemia and to L-dopa administration, his somatic growth was appropriate for his delay in pubertal development, increasing markedly on testosterone treatment. Patients with Klinefelter's syndrome may have abnormalities of neuro-endocrine regulation.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:0256-9574