Dose-response effects of oral loxiglumide on postprandial gall-bladder emptying in man

The effect of two different single oral doses of loxiglumide (CR 1505, CAS 107097-80-3) on gall-bladder emptying induced by a 550-cal standard mixed meal in 6 healthy volunteers was studied. Following placebo, the maximal gall-bladder emptying occurred about 90 min after the meal (minimal residual g...

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Published inArzneimittel-Forschung Vol. 42; no. 11; p. 1359
Main Authors Malesci, A, De Fazio, C, Festorazzi, S, Bonato, C, Valentini, A, Tacconi, M, Bekkering, M, Giacovelli, G, D'Amato, M, Rovati, L C
Format Journal Article
LanguageEnglish
Published Germany 01.11.1992
Subjects
Adult
Cholecystokinin - antagonists & inhibitors
Dose-Response Relationship, Drug
Double-Blind Method
Food
Gallbladder - anatomy & histology
Gallbladder Emptying - drug effects
Humans
Male
Proglumide - analogs & derivatives
Proglumide - pharmacology
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Summary:The effect of two different single oral doses of loxiglumide (CR 1505, CAS 107097-80-3) on gall-bladder emptying induced by a 550-cal standard mixed meal in 6 healthy volunteers was studied. Following placebo, the maximal gall-bladder emptying occurred about 90 min after the meal (minimal residual gall-bladder volume 27.4% of basal volume). Loxiglumide 400 or 800 mg dose-dependently inhibited the physiologica gall-bladder emptying. Loxiglumide plasma levels dose-dependently increased. The inhibition of gall-bladder emptying and the kinetic of loxiglumide plasma levels were temporally related. The results of the present study confirm that oral loxiglumide is a potent orally active cholecystokinin (CCK) antagonist in man and that CCK is the major physiological mediator of gallbladder emptying in response to meal.
ISSN:0004-4172