Drug-protein interactions. Inhibition of the action of levamisole on human serum albumin in vitro by DL-2-oxo-3-(2-mercaptoethyl)-5-phenyl-imidazolidine

Comparative studies by polyacrylamide gel electrophoresis and immunoelectrophoresis showed that DL-2-oxo-3-(2-mercaptoethyl)-5-phenyl-imidazolidine (OMPI), a major metabolite of levamisole in vivo, exerted an inhibitory effect on the polymerization of albumin induced by levamisole action on human se...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 34; no. 7; p. 821
Main Authors Chicault, M, Luu-Duc, C, Boucherle, A
Format Journal Article
LanguageEnglish
Published Germany 1984
Subjects
Biopolymers
Blood Protein Electrophoresis
Humans
Imidazoles - pharmacology
Imidazolidines
Immunoelectrophoresis
In Vitro Techniques
Levamisole - antagonists & inhibitors
Penicillamine - pharmacology
Serum Albumin - metabolism
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Summary:Comparative studies by polyacrylamide gel electrophoresis and immunoelectrophoresis showed that DL-2-oxo-3-(2-mercaptoethyl)-5-phenyl-imidazolidine (OMPI), a major metabolite of levamisole in vivo, exerted an inhibitory effect on the polymerization of albumin induced by levamisole action on human serum in vitro. Similar effects were obtained with sulfhydryl reagents. D-Penicillamine did not indicate such an action. The findings suggest that the SH groups of albumin may be involved in its interaction with levamisole.
ISSN:0004-4172