Urinary fibrin (-ogen) degradation products in Russell's viper (Daboia russelii siamensis) bite victims

Serum and urine concentrations of fibrin (-ogen) degradation products (FDP) were estimated in 20 proven Russell's viper bite (RVB) cases with severe defribination. All patients had similar degrees of high serum FDP levels. However, the ten who developed into acute renal failure (ARF) had signif...

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Published inSoutheast Asian journal of tropical medicine and public health Vol. 24; no. 1; pp. 198 - 201
Main Authors Han, K E, Than, T, Lwin, M, Swe, T N, Pe, T
Format Journal Article
LanguageEnglish
Published Bangkok Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network 01.03.1993
Subjects
Animal poisons toxicology. Antivenoms
Biological and medical sciences
Fibrin Fibrinogen Degradation Products - urine
Humans
Medical sciences
Renal Insufficiency - etiology
Renal Insufficiency - urine
Snake Bites - urine
Toxicology
Tropical medicine
Viper Venoms - toxicity
Thailand
Asia
Human
Urine
Disseminated intravascular coagulopathy
Urinary system disease
Acute
Envenomization
Bite
Animal origin
Hemopathy
Fibrinolysis
Ophidia
Fibrin
Vertebrata
Fibrinogen
Renal failure
Complication
Serum
Reptilia
Coagulopathy
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Summary:Serum and urine concentrations of fibrin (-ogen) degradation products (FDP) were estimated in 20 proven Russell's viper bite (RVB) cases with severe defribination. All patients had similar degrees of high serum FDP levels. However, the ten who developed into acute renal failure (ARF) had significantly (p < 0.001) higher urinary FDP levels than those who did not. The urinary FDP levels of ARF cases increased correspondingly with high serum FDP levels but not in cases without ARF. Serial comparison of serum and urinary FDP levels in RVB cases with severe defibrination may be of value in predicting the likelihood of developing ARF. The present study favored disseminated intravascular coagulation as the main cause of ARF in Myanmar RVB cases.
ISSN:0125-1562