Repeated injections of piracetam improve spatial learning and increase the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in aged rats

Repeated injections of piracetam (400 mg/kg, i.p. once a day for 15 days) to 16-month old rats led to an improved performance on an 8-arm radial maze, used as a test for spatial learning. This effect was accompanied by a greater ability of excitatory amino acids (ibotenate and glutamate) to stimulat...

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Published inFunctional neurology Vol. 6; no. 2; p. 107
Main Authors Canonico, P L, Aronica, E, Aleppo, G, Casabona, G, Copani, A, Favit, A, Nicoletti, F, Scapagnini, U
Format Journal Article
LanguageEnglish
Published Italy 01.04.1991
Subjects
Animals
Cerebral Cortex - drug effects
Cerebral Cortex - physiology
Discrimination Learning - drug effects
Discrimination Learning - physiology
Glutamates - physiology
Glutamic Acid
Hippocampus - drug effects
Hippocampus - physiology
Hydrolysis
Inositol Phosphates - metabolism
Male
Mental Recall - drug effects
Mental Recall - physiology
Orientation - drug effects
Orientation - physiology
Phosphatidylinositols - metabolism
Piracetam - pharmacology
Rats
Rats, Inbred Strains
Receptors, Glutamate
Receptors, Neurotransmitter - drug effects
Receptors, Neurotransmitter - physiology
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Summary:Repeated injections of piracetam (400 mg/kg, i.p. once a day for 15 days) to 16-month old rats led to an improved performance on an 8-arm radial maze, used as a test for spatial learning. This effect was accompanied by a greater ability of excitatory amino acids (ibotenate and glutamate) to stimulate [3H]inositol-monophosphate formation in hippocampal slices incubated in the presence of 10 mM Li+. Repeated administration of piracetam did not induce changes in excitatory amino acid-stimulated polyphosphoinositide hydrolysis in hippocampal slices prepared from 2-month old animals.
ISSN:0393-5264