Polyamine biosynthesis and monooxygenase enzyme activity in rat liver cirrhosis and regeneration

Chemically induced liver cirrhosis in the rat was associated with an increased biosynthesis of the hepatic polyamines putrescine and spermidine and a reduction in the activities of the cytochrome P-450-associated monooxygenase enzymes aryl hydrocarbon hydroxylase, ethoxycoumarin O-deethylase and eth...

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Bibliographic Details
Published inResearch communications in chemical pathology and pharmacology Vol. 53; no. 2; p. 159
Main Authors Raunio, H, Rautio, A, Arranto, A J, Saarni, H U
Format Journal Article
LanguageEnglish
Published United States 01.08.1986
Subjects
7-Alkoxycoumarin O-Dealkylase
Animals
Aryl Hydrocarbon Hydroxylases - genetics
Aryl Hydrocarbon Hydroxylases - metabolism
Carbon Tetrachloride - pharmacology
Cytochrome P-450 CYP1A1
Cytochrome P-450 Enzyme System - metabolism
Liver Cirrhosis, Experimental - chemically induced
Liver Cirrhosis, Experimental - enzymology
Liver Cirrhosis, Experimental - metabolism
Ornithine Decarboxylase - metabolism
Oxidoreductases - genetics
Oxidoreductases - metabolism
Oxygenases - genetics
Oxygenases - metabolism
Polyamines - biosynthesis
Putrescine - metabolism
Rats
Rats, Inbred Strains
Spermidine - metabolism
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Summary:Chemically induced liver cirrhosis in the rat was associated with an increased biosynthesis of the hepatic polyamines putrescine and spermidine and a reduction in the activities of the cytochrome P-450-associated monooxygenase enzymes aryl hydrocarbon hydroxylase, ethoxycoumarin O-deethylase and ethoxyresorufin O-deethylase. These parameters were normalized after a 4-week spontaneous regeneration period. The results suggest an independent regulatory mechanism of polyamine biosynthesis and monooxygenase expression.
ISSN:0034-5164