Hydroxyurea as a suppressor of the radioprotective effect of dextran sulfate on bone marrow hemopoietic stem cells in mice

The changes in hemopoiesis of mice following intraperitoneal administration of dextran sulfate (DS) 24 h before irradiation, as well as the effect of injecting them with hydroxyurea (HU), were analyzed. DS increased the proliferation activity and number of hemopoietic stem cells (CFUs) in the bone m...

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Bibliographic Details
Published inNeoplasma Vol. 37; no. 2; pp. 159 - 166
Main Authors VACEK, A, BARTONICKOVA, A, ROTKOVSKA, D
Format Journal Article
LanguageEnglish
Published Bratislava Slovak Academic Press 1990
Subjects
Animals
Biological and medical sciences
Dextran Sulfate
Dextrans - pharmacology
Female
Hematopoietic Stem Cells - drug effects
Hematopoietic Stem Cells - radiation effects
Hydroxyurea - pharmacology
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Radiation-Protective Agents - pharmacology
Survival Rate
Tumors
Cell proliferation
Gamma irradiation
Pathophysiology
Animal
Hematopoietic cell
Bone marrow
Tumor
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Summary:The changes in hemopoiesis of mice following intraperitoneal administration of dextran sulfate (DS) 24 h before irradiation, as well as the effect of injecting them with hydroxyurea (HU), were analyzed. DS increased the proliferation activity and number of hemopoietic stem cells (CFUs) in the bone marrow. The content of CFUs in the bone marrow and the number of endogenous spleen colonies (ESC) of hemopoietic tissue were higher after irradiation in mice treated with DS than in control groups. The survival rate following a lethal radiation dose was also higher. Injection with HU decreased the number of CFUs in animals injected with DS to the level of controls and suppressed its radioprotective effect.
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ISSN:0028-2685