A unique vascular graft concept for coronary and peripheral applications

Synthetic vascular grafts for coronary bypass (3-4 mm inner diameter [ID], 40-100 ml/min) continue to fail despite success in high flow peripheral applications. A unique method is presented that uses a fluid dynamic approach to improve patency. A large diameter graft (5-6 mm ID) is used with an arte...

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Bibliographic Details
Published inASAIO transactions Vol. 34; no. 3; p. 769
Main Authors Drasler, W J, Jenson, M L, George, S A, Protonotarios, E I, Dutcher, R G, Duncan, P E, Possis, Z C
Format Journal Article
LanguageEnglish
Published United States 01.07.1988
Subjects
Animals
Aorta, Thoracic - surgery
Arteriovenous Shunt, Surgical - methods
Blood Flow Velocity
Blood Vessel Prosthesis
Carotid Arteries - surgery
Coronary Vessels - surgery
Heart Atria - surgery
Hemolysis
Humans
Jugular Veins - surgery
Models, Cardiovascular
Prosthesis Design
Sheep
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Summary:Synthetic vascular grafts for coronary bypass (3-4 mm inner diameter [ID], 40-100 ml/min) continue to fail despite success in high flow peripheral applications. A unique method is presented that uses a fluid dynamic approach to improve patency. A large diameter graft (5-6 mm ID) is used with an arteriovenous (AV) shunt to create a high flow rate (350-650 ml/min); a Venturi flow resistance controls the AV shunt and provides high pressure to the coronary arteries. The resulting graft can supply as many coronary arteries as required by means of side to side anastomoses upstream from the Venturi resistance. The concept was studied in a mock circulation system to analyze fluid dynamics under pulsatile flow. Mathematical models were used to study laminar and turbulent shear stresses and flow distributions over the physiologic range of Reynolds numbers. In vitro testing demonstrated little bovine red blood cell (RBC) hemolysis (0.249 mg Hb/min) compared with other devices. In vivo testing in sheep showed no significant acute changes in pulse rate or blood pressure in response to the shunt. The fluid and mathematical modeling of this concept has additional application in the study of flow past stenoses.
ISSN:0889-7190