Adverse effects of the salazopyrine metabolite sulphapyridine on female fertility in the rat

Salazopyrine, a common therapy for inflammatory bowel disease, is known to have a reversible antifertility effect in men and male rats via its metabolite, sulphapyridine. To determine if there is an adverse effect in females, 20 mature Sprague-Dawley rats were assigned to a treatment (400 mg/kg sulp...

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Bibliographic Details
Published inInternational journal of fertility Vol. 36; no. 3; p. 189
Main Authors Kredentser, J V, McCoshen, J A, Jerome, J, Johnson, K, Cheang, M
Format Journal Article
LanguageEnglish
Published United States 01.05.1991
Subjects
Animals
Chi-Square Distribution
Female
Infertility, Female - chemically induced
Rats
Rats, Inbred Strains
Sulfapyridine - adverse effects
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Summary:Salazopyrine, a common therapy for inflammatory bowel disease, is known to have a reversible antifertility effect in men and male rats via its metabolite, sulphapyridine. To determine if there is an adverse effect in females, 20 mature Sprague-Dawley rats were assigned to a treatment (400 mg/kg sulphapyridine daily), or a control group. After three estrous cycles of treatment, the rats were bred to males of proven fertility. When killed at 10 days gestation, there was a significant reduction in the proportion of fertilized oocytes between control (112/174) and treatment (81/212) groups (chi-square = 26.16, d.f. = 1, P less than .00001). These findings suggest an adverse effect of sulphapyridine on female fertility.
ISSN:0020-725X