Anemia prevalence and associated risk factors in a single-center ambulatory HIV clinical cohort

The prevalence of anemia in HIV-infected persons has not been well characterized in the HAART era. In a single-center, retrospective study, anemia prevalence and risk factors, including use of HAART, were assessed in an ambulatory clinical cohort of 758 HIV-infected patients for the calendar year 20...

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Published inThe AIDS reader Vol. 14; no. 6; p. 305
Main Authors Wills, Todd S, Nadler, Jeffrey P, Somboonwit, Charurut, Vincent, Albert, Leitz, Gerhard, Marino, Kimberly, Naik, Eknath, Powers, Stacy, Khan, Nadeem, Laartz, Brent
Format Journal Article
LanguageEnglish
Published United States 01.06.2004
Subjects
Adolescent
Adult
Aged
Ambulatory Care
Anemia - complications
Anemia - epidemiology
Antiretroviral Therapy, Highly Active - adverse effects
Cohort Studies
Cross-Sectional Studies
Female
Florida - epidemiology
HIV Infections - complications
HIV Infections - drug therapy
Humans
Male
Middle Aged
Prevalence
Retrospective Studies
Risk Factors
Viral Load
Florida
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Summary:The prevalence of anemia in HIV-infected persons has not been well characterized in the HAART era. In a single-center, retrospective study, anemia prevalence and risk factors, including use of HAART, were assessed in an ambulatory clinical cohort of 758 HIV-infected patients for the calendar year 2000. The relationships between anemia (hemoglobin level less than 12.5 g/dL) and demographic variables, antiretroviral treatment regimens, and disease markers were analyzed. Mean baseline patient characteristics were hemoglobin level, 13.7 +/- 1.9 g/dL; CD4+ cell count, 405 +/- 293/microL; and HIV RNA level, 77,841 +/- 148,394 copies/mL. Overall anemia prevalence was 30.3%. Multivariate logistic regression analysis demonstrated that anemia was associated with a CD4+ cell count below 50/microL, female sex, black race, a viral load above 100,000 copies/mL, zidovudine use, and older age. Severe anemia was less prevalent in this study population than in historical comparators; however, mild to moderate anemia rates remain high.
ISSN:1053-0894