Polysaccharide Peptide (PsP) of Ganoderma lucidum as vasa vasorum anti-Angiogenesis agent in Dyslipidemic state by Measuring Lp-PLA2 and H2O2 Levels: In Vivo Study using wistar strain Rattus novergicus model of Atherosclerosis with Dyslipidemia

• Published in: Research journal of pharmacy and technology Vol. 13; no. 7; pp. 3241 - 3245
• Main Authors: Wihastuti, Titin Andri, Cesa, Fibe Yulinda, Amiruddin, Reyhan, Setiawan, Meddy, Wijayanti, Danisa Namira, Heriansyah, Teuku
• Format: Journal Article
• Language: English
• Published: Raipur A&V Publications 01.07.2020
• Subjects: Angiogenesis; Antioxidants; Atherosclerosis; Cardiovascular disease; Coronary vessels; Enzymes; Free radicals; Lipids; Lipoproteins; Metabolic disorders; Mortality; Oxidative stress; Peptides; Surgery; Indonesia
• ISSN: 0974-3618; 0974-306X
• DOI: 10.5958/0974-360X.2020.00574.0

Cardiovascular diseases are the leading cause of death globally, contributing to around 31% of mortality worldwide, and more than 75% mortality in low-middle income countries1. OxLDL could initiate chemoattractants release, which will further induce macrophage migration to the lesion site, and reactive oxygen species (ROS) generation, and produce cascades of oxidative stress. In other words, OxLDL is capable of inducing chronic inflammatory response OxLDL is degraded into lysophosphatidylcholie and oxidized nonesterified fatty acid by lipoprotein associated phospholipase (Lp-PLA2) which has proinflammatory properties, and hypothesized by several researchers as a marker of atherosclerotic plaque development7. High fat diet administration caused dyslipidemia, which manifested as the increase of body LDL concentration 25,26 Development of vasa vasorum angiogenesis in rat with High Fed Diet administration corresponds to vascular oxidative stress process.