A new marker for lipid peroxidation: serum paraoxonase activity in non-alcoholic steatohepatitis

• Published in: The Turkish journal of gastroenterology Vol. 16; no. 3; pp. 119 - 123
• Main Authors: Başkol, Mevlüt, Başkol, Gülden, Deniz, Kemal, Ozbakir, Omer, Yücesoy, Mehmet
• Format: Journal Article
• Language: English
• Published: Turkey Türk Gastroenteroloji Vakfı 01.09.2005
• Subjects: Adult; Arildialkilfosfataz; Aryldialkylphosphatase; Aryldialkylphosphatase - blood; Biomarkers - blood; Body Mass Index; Case-Control Studies; Digestive system diseases; Fatty Liver; Fatty Liver - blood; Fatty Liver - enzymology; Female; Hepatit, kronik; Hepatitis B - blood; Hepatitis B - enzymology; Hepatitis C - blood; Hepatitis C - enzymology; Hepatitis, Chronic; Humans; Hypercholesterolemia - enzymology; Hypertriglyceridemia - enzymology; Lipid peroksidasyonu; Lipid Peroxidation; Male; Malondialdehit; Malondialdehyde; Malondialdehyde - blood; Middle Aged; Obesity - enzymology; Severity of Illness Index; Sindirim sistemi hastalıkları; Turkey; Yağlı karaciğer; Turkey
• ISSN: 1300-4948

Relationship between hepatic antioxidant paraoxonase 1 (PON1) activity, lipid peroxidation and liver injury was investigated in patients with non-alcoholic steatohepatitis. A total of 23 patients with non-alcoholic steatohepatitis (15 males, 8 females; mean age: 40.30+/-7.67 yrs) and 23 healthy controls (14 males, 9 females; mean age: 39.70+/- 8.78 yrs) were enrolled in the study. Serum paraoxonase 1 activity and levels of a well-known lipid peroxidation marker, serum malondialdehyde, were determined. Serum paraoxonase 1 activity decreased significantly in non-alcoholic steatohepatitis compared to the control group (p<0.01). Serum malondialdehyde levels were significantly higher in patients with non-alcoholic steatohepatitis as compared with the control group (p<0.05). No statistically significant correlations were found between serum paraoxonase 1 activities and the grade-stage of non-alcoholic steatohepatitis, serum lipid levels or serum malondialdehyde levels (p>0.05). Increased lipid peroxidation may be either a cause or a result of liver injury in patients with non-alcoholic steatohepatitis. Although serum paraoxonase 1 activity does not reflect the degree of liver damage in non-alcoholic steatohepatitis, reduced paraoxonase 1 activity, especially in the presence of mild disease, could be interpreted as a biochemical marker of the lipid peroxidation.