TOR-dependent cerebrovascular aging in Alzheimer's disease
Increasing evidence suggests that vascular dysfunction, a universal feature of aging, mechanistically contributes to the onset and pathogenesis of neurological diseases of aging. It was recently discovered that attenuating activity of the mammalian/mechanistic target of rapamycin (mTOR) extends both...
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Published in | Current trends in neurology Vol. 8; p. 31 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
India
2014
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Subjects | |
Online Access | Get more information |
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Summary: | Increasing evidence suggests that vascular dysfunction, a universal feature of aging, mechanistically contributes to the onset and pathogenesis of neurological diseases of aging. It was recently discovered that attenuating activity of the mammalian/mechanistic target of rapamycin (mTOR) extends both life- and health-span in mice by delaying aging. Here we review current evidence for a critical role of mTOR in age-associated vascular dysfunction and discuss potential mechanisms by which this pathway may lead to cognitive decline in Alzheimer's disease. |
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ISSN: | 0972-8252 |