TOR-dependent cerebrovascular aging in Alzheimer's disease

Increasing evidence suggests that vascular dysfunction, a universal feature of aging, mechanistically contributes to the onset and pathogenesis of neurological diseases of aging. It was recently discovered that attenuating activity of the mammalian/mechanistic target of rapamycin (mTOR) extends both...

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Bibliographic Details
Published inCurrent trends in neurology Vol. 8; p. 31
Main Authors Jahrling, Jordan B, Galvan, Veronica
Format Journal Article
LanguageEnglish
Published India 2014
Subjects
aging
Alzheimer’s disease
cognitive decline
vascular
TOR
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Summary:Increasing evidence suggests that vascular dysfunction, a universal feature of aging, mechanistically contributes to the onset and pathogenesis of neurological diseases of aging. It was recently discovered that attenuating activity of the mammalian/mechanistic target of rapamycin (mTOR) extends both life- and health-span in mice by delaying aging. Here we review current evidence for a critical role of mTOR in age-associated vascular dysfunction and discuss potential mechanisms by which this pathway may lead to cognitive decline in Alzheimer's disease.
ISSN:0972-8252