Factors affecting oxidative damage in obese children: an exploratory study

• Published in: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 31; no. 4; pp. 1499 - 1503
• Main Authors: Rentería, Ivan, Arenas Berumen, Ever, Arellano García, María Evarista, Carrasco-Legleu, Claudia Esther, De León-Fierro, Lidia Guillermina, Arenas-Berumen, Enrique Alejandro
• Format: Journal Article
• Language: Spanish
• Published: Spain 01.04.2015
• Subjects: Antioxidants - metabolism; Body Mass Index; Child; DNA Damage; Female; Humans; Male; Metabolic Syndrome - genetics; Metabolic Syndrome - metabolism; Obesity - metabolism; Oxidative Stress; Risk Factors
• ISSN: 1699-5198
• DOI: 10.3305/nh.2015.31.4.8508

Obesity is a metabolic disorder that creates oxidizing conditions, which can generate high levels of physiological stress as well as a disturbance in the state of redox cell known as Oxidative Stress. To examine the association between the damage on chromosomal DNA and the total antioxidant capacity (TAC) in obese children with severe obesity. Participants were 11 children with a mean age and body mass index of 9.5±1.2 years and 27.7±3.3 kg/m2, respectively, from which venous blood samples were obtained to determine distinctive risk factors of metabolic syndrome, the number of DNA abasic sites (AS) and TAC levels. Biomarkers were quantified from spectrophotometric techniques and ELISA assays. Were identified 4.1±4.0x105 AS and TAC of 0.218±0.03 mmol/L, and an inverse correlation between AS and TAC (r = -0.63, p=0.038). These results suggest an imbalance in reduction-oxidation status (REDOX) within the cell. Increased AS and decreased TAC concentrations in the presence of severe obesity suggest that oxidative stress could be considered as an important risk factor closely linked to the early development of comorbidities associated to obesity.