Effectiveness of "threshold" in the management of ovarian cancer: A review of the literature

• Published in: Bulletin du cancer Vol. 103; no. 6; p. 513
• Main Authors: Seror, Julien, Guillot, Eugénie, Genin, Anne-Sophie, Hequet, Delphine, Pouget, Nicolas, Dubot, Coraline, Rouzier, Roman
• Format: Journal Article
• Language: French
• Published: France 01.06.2016
• Subjects: Cancer Care Facilities - statistics & numerical data; Female; Genital Neoplasms, Female - mortality; Genital Neoplasms, Female - surgery; Hospitals, High-Volume - statistics & numerical data; Hospitals, Low-Volume - statistics & numerical data; Humans; Ovarian Neoplasms - mortality; Ovarian Neoplasms - surgery; Prospective Studies; Retrospective Studies; Surgeons - statistics & numerical data; Survival Analysis; Volume; Surgery; Seuil; Chirurgie; Cancer de l’ovaire; Survie; Survival; Ovarian cancer; Threshold
• ISSN: 1769-6917
• DOI: 10.1016/j.bulcan.2016.03.010

The "Institut national du cancer" has established since 2007 a minimum threshold of 20 patients per year per center to treat patients with gynecologic cancer. This review aims to assess whether the literature data validate this approach, and specifically for ovarian cancer. A search of the MEDLINE database was conducted, to reference all relevant articles evaluating one hand the links between the survival of patients with ovarian cancer and the average volume of patients per center and by operator; and secondly the relationship between quality of oncological surgery and these volumes. Nineteen studies met our inclusion criteria; seventeen were retrospective and two were prospective; population samples ranged from 476 to 96,802 patients. The most important data, quantitatively and qualitatively, concern the evaluation of survival based on the average volume per center, with 8 out of 13 studies finding a statistically significant correlation between average volume per center and survival. Data on the quality of surgery are less abundant and more heterogeneous, depending on the definition of the "optimal" surgery by the authors. The establishment of threshold centers appears to be an effective way to improve survival in ovarian cancer. However, these thresholds would have to be specific to ovarian cancer and not extended to "gynecological cancers."