Directed Amination of Non-Acidic Arene CH Bonds by a Copper-Silver Catalytic System

Amine meets arene: A method for direct amination of [beta]-C(sp(2))-H bonds of benzoic acid derivatives and γ-C(sp(2))-H bonds of benzylamine derivatives has been developed. The reaction is catalyzed by Cu(OAc)2 and a Ag2CO3 cocatalyst, and shows high generality and functional-group tolerance, as we...

Full description

Saved in:
Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 52; no. 23; pp. 6043 - 6046
Main Authors Ly Dieu Tran, Roane, James, Daugulis, Olafs
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 03.06.2013
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
PALLADIUM
ACTIVATION
METAL-FREE CONDITIONS
DIRECT ARYLATION
AMIDATION
CARBON-HYDROGEN BONDS
FUNCTIONALIZATION
CH activation
arenes
TEMPERATURE
copper
amination
H BONDS
SP
Online AccessGet full text

Cover

More Information
Summary:Amine meets arene: A method for direct amination of [beta]-C(sp(2))-H bonds of benzoic acid derivatives and γ-C(sp(2))-H bonds of benzylamine derivatives has been developed. The reaction is catalyzed by Cu(OAc)2 and a Ag2CO3 cocatalyst, and shows high generality and functional-group tolerance, as well as providing a straightforward means for the preparation of ortho-aminobenzoic acid derivatives.
Bibliography:NIH RePORTER
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201300135