Types of bcr-abl and their correlations with the blood count in chronic myeloid leukemia (CML) in Togo

This study aims to describe the different bcr-abl gene transcript variants in order to determine their frequency and to study their influence on CBC diagnostic test. We conducted a cross-sectional study of 34 patients with chronic myeloid leukemia in Togo. The search for fusion transcripts was perfo...

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Published inThe Pan African medical journal Vol. 30; p. 221
Main Authors Padaro, Essohana, Magnang, Hèzouwè, Layibo, Yao, Mawussi, Koffi, Kuéviakoé, Irénée Messanh, Agbétiafa, Kossi, Vovor, Ahoéfa
Format Journal Article
LanguageFrench
Published Uganda 2018
Subjects
Adolescent
Adult
Aged
Blood Cell Count
Child
Cross-Sectional Studies
Female
Fusion Proteins, bcr-abl - genetics
Hemoglobins - metabolism
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Male
Middle Aged
Togo
Young Adult
Togo
Lomé (Togo)
bcr-abl
Chronic myeloid leukemia
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Summary:This study aims to describe the different bcr-abl gene transcript variants in order to determine their frequency and to study their influence on CBC diagnostic test. We conducted a cross-sectional study of 34 patients with chronic myeloid leukemia in Togo. The search for fusion transcripts was performed in the laboratory of biological haematology at the Henri Mondor Hospital, Créteil (France). The average age of patients was 42,32±14,87 years ranging between 9 and 65 years. Most patients were male, with a sex- ratio of 1.61 (21 men and 13 women). Molecular examination showed b3-a2 transcript and b2-a2 transcript. Nineteen patients (55.88%) expressed b3-a2 transcript, 13 patients (38.24%) b2-a2 transcript (32.10%) and two patients expressed both b3-a2 and b2-a2 transcripts (5.88%). At diagnosis, mean hemoglobin level, the average number of white blood cells and the average number of platelets in patients expressing b3-a2 transcript were 99,2g/L; 207,63g/l and 451,28g/l respectively. In patients expressing b2-a2 transcript values were 104,6g/l, 114,32g/l and 486,11g/l. In patients with both transcripts, values were 67g/L, 867g/l and 780g/l respectively. CBC parameters are more significantly altered in patients with both transcripts b3-a2 and b2-a2.
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ISSN:1937-8688
DOI:10.11604/pamj.2018.30.221.9821