Myeloperoxidase in the neurodegenerative process of Parkinson's disease

• Published in: Deutsche medizinische Wochenschrift (1946) Vol. 139; no. 3; p. 99
• Main Author: Teismann, P
• Format: Journal Article
• Language: German
• Published: Germany 01.01.2014
• Subjects: Animals; Astrocytes - pathology; Astrocytes - physiology; Cell Count; Dopamine - metabolism; Free Radicals; Humans; Inclusion Bodies - pathology; Inclusion Bodies - physiology; Inflammation Mediators - blood; Mice; Nerve Degeneration - pathology; Nerve Degeneration - physiopathology; Neural Pathways - pathology; Neural Pathways - physiopathology; Oxidative Stress - physiology; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Parkinsonian Disorders - pathology; Parkinsonian Disorders - physiopathology; Peroxidase - physiology; Reactive Oxygen Species; Substantia Nigra - pathology; Substantia Nigra - physiopathology
• ISSN: 1439-4413
• DOI: 10.1055/s-0033-1359907

Myeloperoxidase (MPO) is a hemoprotein which is involved in the unspecific immune response. In this process hypochloric acid is released. Hypochloric acid can react with lipids and proteins and thus lead to cell damage. We were able to show that MPO, as well as a biomarker for MPO - 3-Chlorotyrosine - are upregulated in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-model of Parkinson's disease as well as in the disease itself. Ablation of MPO resulted in a neuroprotective effect in the MPTP-model. Herein we describe the different function of MPO, and how these can lead to the cellular demise as seen in Parkinson's disease.