Simultaneous determination of seven quaternary ammonium compounds in frozen food by ultra performance liquid chromatography-tandem mass spectrometry combined with modified QuEChERS method

• Published in: Se pu = Chinese journal of chromatography Vol. 41; no. 3; p. 233
• Main Authors: Liu, Bo-Lin, Zhao, Zi-Wei, Zhan, Zi-Yue, Dai, Yan-Yu, Ding, Gang, Xie, Ji'an, Xu, Xiang-Chuan, Kong, Hong-Tao
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2023
• Subjects: Chromatography, Liquid; Frozen Foods; Humans; Male; Methanol; Prostate-Specific Antigen; Quaternary Ammonium Compounds; Tandem Mass Spectrometry; quaternary ammonium compounds (QACs); frozen food; QuEChERS; ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)
• ISSN: 1872-2059
• DOI: 10.3724/SP.J.1123.2022.05008

Quaternary ammonium compounds (QACs) are a class of cationic surfactants that can be used as the main active ingredient of disinfectants. The increased use of QACs is concerning as exposure from inhalation or ingestion to these compounds that has been associated with adverse effects on the reproductive and respiratory systems. Humans are exposed to QACs primarily by food consumption and inhalation of air. QAC residues pose significant threats to public health. Given the importance of assessing potential residue levels for QACs in food, therefore, a method was developed for the simultaneous detection of six common QACs and one emerging QAC (Ephemora) in frozen food by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) coupled with the modified QuEChERS method. The main factors governing the response, recovery, and sensitivity of the method, including extraction solvents, types and dosages of adsorbents, apparatus conditions, and mobile phases, were optimized in the course of sample p