Genetic predictors of sick sinus node syndrome

The article is devoted to the role of heredity in development of the sick sinus node syndrome (SSNS). We have examined 14 probands and 110 their relatives from families with idiopathic SSNS and established the role in development of hereditary SSNS of polymorphisms of the following genes: -2-adrenor...

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Bibliographic Details
Published inKardiologiia Vol. 53; no. 6; p. 12
Main Authors Chernova, A A, Nikulina, S Iu, Tret'iakova, S S
Format Journal Article
LanguageRussian
Published Russia (Federation) 2013
Subjects
Adult
Aged
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Middle Aged
Polymorphism, Genetic
Sick Sinus Syndrome - genetics
Sick Sinus Syndrome - physiopathology
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Summary:The article is devoted to the role of heredity in development of the sick sinus node syndrome (SSNS). We have examined 14 probands and 110 their relatives from families with idiopathic SSNS and established the role in development of hereditary SSNS of polymorphisms of the following genes: -2-adrenoreceptor, enzyme endothelial NO synthase, protein connexin 40, voltage dependent cardiac sodium channels, cardiac myosin heavy chains. We also revealed associations of clinical variants of idiopathic SSNS with genotypes of the studied genes.
ISSN:0022-9040